You are watching: Which of the following statements about cancer cells is false?
People infected through HIV are even more susceptible to obtaining specific kinds of cancer bereason a. the virus encodes a protein that binds and inactivates the tumor suppressor gene p53. b. these people are immunosuppressed. c. the virus integprices into the genome and transforms the pattern of expression of surrounding genes. d. of the expression of the viral gene taxation.
What is the difference in between a benign tumor and a malignant tumor? a. A malignant tumor is painful, and also a benign tumor is not. b. A malignant tumor has the ability to spread to various other tconcerns and also to initiate tumors at additional sites, whereas a benign tumor does not spreview. c. A benign tumor will cause a much less serious develop of cancer than a malignant tumor. d. A malignant tumor is led to by a virus, whereas a benign tumor arises spontaneously.
b. A malignant tumor has actually the capability to spcheck out to various other tconcerns and to initiate tumors at additional sites, whereas a benign tumor does not spread.
Which of the adhering to genes is expressed by SV40 (simian virus 40) and induces transformation? a. The gene encoding big T antigen b. E1A c. E6 d. E1B
Oncogenic convariation of the two dimerizing proto-oncogene components of the AP-1 transcription aspect can bring about abnormal cell proliferation. Which of the complying with 2 gene products form the energetic AP-1 transcription element complex? a. Fos and Jun b. Fos and Myc c. Myc and Jun d. Raf and Myc
The PDGF receptor is a proto-oncogene (a normal cellular gene that, once mutated, becomes oncogenic). Which of the complying with statements around the PDGF receptor is true? a. The oncogenic mutation occurs in the extracellular amino terminal end of the receptors. b. The oncogenic mutation constitutively activates the intracellular kinase task of the protein. c. The oncogenic mutation generates a receptor that is no longer dependent on ligand for activation. d. All of the above
Burkitt"s lymphoma is caused nearly solely by a. point mutations in the ras proto-oncogene. b. transplace of the abl proto-oncogene. c. transplace of the c-myc proto-oncogene. d. amplification of the N-myc gene.
Pioneering work-related by Judah Folkmale led to a course of anticancer drugs, such as sunitinib and sorafenib. These drugs attribute by a. inhibiting DNA replication. b. binding and also inhibiting the ErbB-2 oncogene protein, which is overexpressed in many type of breastern cancers. c. inhibiting the formation of brand-new blood vessels in the vicinity of the tumor. d. inhibiting farnesylation.
Which of the complying with has not been uncovered to reason cancer? a. Chemicals b. Radiation c. Bacteria d. Viruses
Which of the complying with statements concerning the distinction between cancer cells and normal cells is false? a. Regular cells display density-dependent inhibition of cell proliferation. b. Cancer cells have reduced needs for extracellular expansion determinants. c. Malignant cells generally secrete proteases that digest extracellular matrix components. d. Cancer cells undergo normal differentiation, but too much proliferation.
The most lethal type of cancer in the USA is cancer of the a. prostate. b. colon/rectum. c. breast. d. lung.
Which of the following tumor suppressor genes has actually been linked with colon cancer? a. APC b. p53 c. Smad2 or Smad4 d. All of the above
Which of the adhering to statements around papillomavirsupplies is false? a. They induce both benign and malignant tumors in humans. b. They have been presented to reason both benign and malignant breastern cancer. c. They mostly infect epithelial cells. d. Upon infection, they reason expression of E6 and also E7, which induce transformation.
Which of the adhering to statements around the tumor suppressor gene p53 is false? a. It plays a function in up to 50% of huguy cancers. b. It is the reason of the rare childhood cancer of the eye, retinoblastoma. c. It blocks cell cycle development in response to DNA damages. d. It is forced for apoptosis in response to DNA damages.
Which of the adhering to is not one of the methods in which oncogenes incorporated into viral genomes can differ from their normal cellular countercomponents (proto-oncogenes)? a. They have the right to contain fusions to viral sequences, bring about structural alters that demanage the protein. b. They deserve to contain point mutations in regulatory domain names, leading to a loss of protein regulation. c. They deserve to be current in many kind of tandem duplicates, as opposed to the single copy existing in the cell. d. They have the right to be expressed from much more powerful promoters than the normal cellular promoter.
Angiogenesis contributes to cancer advance by a. offering nutrients and oxygen to tumors and also by facilitating metastasis. b. initiating a mutation in a gene that causes uncontrolled cell expansion. c. inhibiting apoptosis (programmed cell death). d. avoiding the normal inhibition of expansion that occurs between cells on contact.
PTEN is a tumor suppressor gene in the Akt signaling pathmeans. Which of the adhering to statements about PTEN/Akt is false? a. PIP2 deserve to be oncogenically mutated to induce cell survival. b. PTEN antagonizes (has the opposite effect) of PI 3-kinase. c. Akt deserve to be oncogenically mutated to induce cell survival. d. It is a lipid phosphatase that dephosphorylates PIP3 to PIP2.
The more than 40 oncogenic retroviruses that have actually been figured out share expression of all of the following genes except a. src. b. pol. c. env. d. gag.
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Infection via which of the adhering to viruses is connected with breakthrough of liver cancer in humans? a. Simian virus 40 (SV40) b. Hepatitis B viruses c. Epstein-Barr virus d. Papillomaviruses
The majority of oncogene proteins are a. metabolic enzymes. b. structural proteins, such as nuclear lamins. c. proteins involved in cell sorting. d. components of signaling pathmethods that control cell proliferation.