Why the Bills" pass rush can be key vs. the Steelers (0:34)Mina Kimes defines why the Bills" protective line gives them the edge versus the Steelers. (0:34)


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Stat to know: The Viemperors enabled 40.0 points per game in their final three 2020 games, yet they haven"t enabled 30-plus points in four consecutive games because the 2012-13 seasons.

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Injuries: Vimajesties | Bengals

What to recognize for fantasy: Cook had one weakness last seakid, and also that was his 3.7 yards per bring on up-the-gut runs, a rate that ranked 30th of 47 qualifiers. Well, the 5.2 yards per carry that Cincinnati permitted to RBs on such runs last season wasn"t simply a league high, it was the a lot of by an AFC defense given that the 2012 Bills. See Week 1 rankings.

Betting nugget: The Bengals were just 1-7-1 outideal via Burrow beginning, yet they did control to cover 5 of those contests. Read more.

Cronin"s pick: Viemperors 23, Bengals 20Baby"s pick: Bengals 31, Vimajesties 28FPI prediction: MIN, 52.7% (by an average of 1.1 points)

Matchup must-reads: Vikings rookie LT Darriwitnessed to return to exercise Wednesday ... How Burrow"s enhanced velocity can have actually Bengals thinking playoffs ... O"Neill indicators five-year extension through Vimonarchs worth $92.5 million, resource says ... How Bengals security Bates is making use of meditation to prepare for a pivotal 2021 season


49ers at Lions

1 p.m. ET | FOXMatchup rating: 41.0 | Spread: SF -7.5 (44.5)

What to watch for: It"s truly a new era in Detroit, through Jared Goff set to become the initially quarterago external of Matthew Stafford to begin a seaboy opener since 2008. Tbelow aren"t many type of expectations for Detroit to win more than 5 regular-season games, so players seem to be embracing an underdog role this seakid. Lions tight end T.J. Hockenchild is cshed friends with and a former college teammate of the 49ers" George Kittle, so that"ll be a matchapproximately watch for bragging civil liberties at the position. -- Eric Woodyard

Bold prediction: Much of the talk about the Niners going into this one centers on the quarterbacks, yet it will be the run game -- led by earlier Raheem Mostert -- that will certainly steal the display. Mostert will certainly run for 150-plus yards and a pair of touchdowns versus a Detroit defense that finiburned 28th in rushing yards permitted per game and provided up a league-high 27 rushing touchdowns in 2020, and also then didn"t make many type of significant moves to enhance in that area in the offseaboy. -- Nick Wagoner

Stat to know: The 49ers are 15-2 versus the Lions dating earlier to 1988, the ideal record by a team versus a single enemy in that expectations (minimum 10 meetings).

Injuries: 49ers | Lions

What to know for fantasy: The highest-scoring career dehowever by a non-QB last season was 21.3 points from Bills running earlier Antonio Williams. That number could be within reach for Niners RB Trey Sermon against a Lions defense that allowed a league-high 32.5 fantasy points per game to the position last season. See Week 1 rankings.


Eagles at Falcons

1 p.m. ET | FOXMatchup rating: 32.8 | Spread: ATL -3 (48.5)

What to watch for: This is the deyet for both head coaches -- Arthur Smith via Atlanta, and Nick Sirianni through Philadelphia -- and also it has actually resulted in a little bit of system mystery for both teams. Neither the Eagles nor Falcons verified a lot of their offenses or defenses throughout training camp. "The benefits that I think we have actually is that they do not know what we"re going to execute and also we don"t understand what they"re going to execute," Sirianni sassist. "So simply kind of a blank slate ideal tright here." -- Michael Rothstein

Bold prediction: Eagles cornerago Darius Slay will record his third career interception against quarterearlier Matt Ryan, sparking a bounce-ago year. Ryan had an abysmal day the last time these 2 challenged off, throwing three picks -- two to Slay -- in a 2017 matchup between the Falcons and also Detroit Lions. Slay, 30, is focused on generating even more takeamethods this seakid after posting simply one interception in 2020. Playing in defensive coordinator Jonathan Gannon"s takeaway-obsessed plan need to help. -- Tim McManus

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Stat to know: At 23 years and also 36 days old, Philadelphia QB Jalen Hurts will surpass Carkid Wentz and Donovan McNabb as the youngest Eagles season-opening starter in the Super Bowl era. Both Wentz and McNabb won those openers, and while Hurts was 1-3 as the starting QB last seakid, the Eagles averaged 382.0 yards per game in his starts as opposed to 318.8 in Wentz"s starts.

Injuries: Eagles | Falcons

What to recognize for fantasy: Falcons receiver Calvin Ridley led the NFL in air yards last seaboy via 2,042, and he faces an Eagles defense that didn"t turn over the opposition on deep passes last seaboy (2% deep interception rate, fourth lowest). See Week 1 rankings.

Betting nugget: The Eagles were just 1-7, both outideal and ATS, on the road last season. Read more.

McManus" pick: Eagles 34, Falcons 26Rothstein"s pick: Falcons 31, Eagles 27FPI prediction: ATL, 63.0% (by an average of 4.8 points)

Matchup must-reads: Eagles walk fine line in keeping Goedert, Ertz ... Why Pees joined the Falcons and is still scheming up defenses as he turns 72 ... Why Sanders can have actually a bust-out season for Eagles ... Eagles" difficult love helping Mailata grow in Philadelphia


Jets at Panthers

1 p.m. ET | CBSMatchup rating: 32.1 | Spread: CAR -4 (44)

What to watch for: This is all around former Jets quarterback Sam Darnold -- now founding via the Panthers -- and also new Jets quarterback Zach Wilkid. Whomever before gets the best protection and is the many effective will certainly come out ahead, and also both defensive coordinators will aim to get the opposing quarterbacks out of their comfort areas. -- David Newton

Bold prediction: Panthers running earlier Christian McCaffrey will have double-digit receptions for the 11th time in his career. He will certainly be a matchup nightmare for the Jets, that do not have anyone that deserve to cover him. C.J. Mosley isn"t great in coverage, and the other linebackers are rookies. New York could attempt utilizing safety Lamarcus Joyner, that has actually suffer as a slot edge. -- Rich Cimini

Stat to know: This is the first circumstances of a top-three-drafted QB starting his initially NFL game versus another selected by the exact same franchise.

Injuries: Jets | Panthers

What to know for fantasy: Because Week 14 of 2019, McCaffrey has 6 games through at least 24.5 fantasy points, a number that trails only Derrick Henry at the place over that stretch. And McCaffrey has actually played in only seven of those 21 weeks. See Week 1 rankings.

Betting nugget: No team covered fewer games in the initially fifty percent of last season than the Jets, but just four groups (Bills, Saints, Ravens and Dolphins) extended more in the second percentage of the seachild. Read more.

Cimini"s pick: Panthers 31, Jets 24Newton"s pick: Panthers 27, Jets 17FPI prediction: CAR, 65.7% (by an average of 5.9 points)

Matchup must-reads: Wilson, Darnold firmly insist Jets-Panthers opener not about outdueling each various other ... Darnold concentrated on second opportunity through Panthers, not revenge versus Jets ... Can Jets" coach-QB duo of Saleh, Wilchild flip the franchise? ... Jets go young (12 rookies!): Short-term pain, irreversible gain


Jaguars at Texans

1 p.m. ET | CBSMatchup rating: 11.3 | Spread: JAX -3 (45.5)

What to watch for: Can rookie quarterback Trevor Lawrence find success against a depleted Texans secondary? Houston was already going to be without cornerback Bradley Roby (he is finishing out his six-game suspension in Week 1) however also has actually injury pertains to via safety Lonnie Johnson. Johnson, that is handling a thigh injury, did not practice Wednesday. -- Sarah Barshop

Bold prediction: Texans QB Tyrod Taylor will throw for fewer than 200 yards. He has made 2 previous starts versus the Jaguars and also hasn"t thrvery own for more than 166 yards in them. The last time he began a game versus the Jaguars came in the 2017 playoffs, and also he threw for just 134 yards in a 10-3 loss. The Jaguars have actually reconstructed their additional through the enhancement of protective backs Shaquill Griffin, Tykid Campbell, Rayshawn Jenkins and Andre Cisco, and protective coordinator Joe Cullen likes to speak to many blitzes, so the Jaguars should make it a challenging day for Taylor. -- Mike DiRocco

Stat to know: A few not-so-excellent streaks are in play here. The Jaguars have lost a franchise-document 15 straight games, which is tied for the 10th-longest losing streak given that the NFL merger in 1970. They also have actually 18 straight games enabling at leastern 20 points, tied for the fifth-longest streak because 1970. The Texans, meanwhile, have shed four right seachild openers, tied via Giants for the second-longest energetic streak in the NFL.

Injuries: Jaguars | Texans

What to understand for fantasy: Due to the fact that 2016, only Mike Evans and also Julio Jones have actually more deep receptions than Texans receiver Brandin Cooks, who lines up versus a Jags defense that allowed the fifth-most yards per deep completion last seaboy (28.8). See Week 1 rankings.

See more: Yet Another Hunter Timer - Kharthus'S Hunter Timers

Betting nugget: This is simply the 3rd time in the past 15 seasons that Jacksonville has been a road favorite in a division game, and also it"s the first time considering that 2017. Read more.

DiRocco"s pick: Jaguars 24, Texans 17Barshop"s pick: Jaguars 24, Texans 21FPI prediction: JAX, 51.5% (by an average of 0.6 points)

Matchup must-reads: QB Lawrence "excited" to be called among Jaguars" captains as rookie ... Texans" Taylor embraces basic philosophy: "Control what you deserve to control" ... How bad does Vegas think the Texans are going to be in 2021?


Browns at Chiefs

4:25 p.m. ET | CBSMatchup rating: 76.1 | Spread: KC -5.5 (54.5)

What to watch for: The Chiefs will begin two rookies and also a first-year player (Lucas Niang opted out in 2020) on their offensive line, but no member of that team will certainly be under even more scrutiny than veteran Orlando Brown Jr., that renders his Kansas City deyet at left tackle against the Browns" Myles Garrett. The Chiefs" rebuilt offensive line, through five new starters from last season, verified well in the preseakid but encounters a bigger challenge against Garrett and the Browns. In his one begin at left tackle for the Ravens against the Browns last seaboy, Brvery own held Garrett without a sack, one of the four games in which Garrett was shut out. -- Adam Teicher